Tuesday, March 10, 2009

Malignant Mesothelioma

Malignant Mesothelioma

Malignant mesothelioma is a rare form of cancer that affects the mesothelial cells around the heart, lungs or abdominal organs. The most common type of mesothelioma is the one which affects the pleura, the thin membrane between the lungs and the chest cavity. This type of the disease is known as Pleural Mesothelioma, and sufferers can experience symptoms which include: shortness of breath, breathing difficulties, persistent coughing, chest pains, weight loss, and trouble swallowing.

Peritoneal Mesothelioma is another form of this disease but is not as common as Pleural Mesothelioma. This type of the disease affects the peritoneum membrane of the abdomen. These tumors can also be found in the stomach and abdominal organs. Sufferers of Peritoneal Mesothelioma can experience symptoms which include: stomach pains and abdominal swelling, nausea, loss if appetite, vomiting, bowel obstruction, and blood clotting abnormalities.

The third and the rarest type of mesothelioma is Pericardial Mesothelioma, which affects the tissue and cavity surrounding the heart. Patients of this type of the disease may experience symptoms such as shortness of breath, chest pains, persistent coughing and palpitations.

Malignant mesothelioma is a fatal disease caused by exposure to asbestos. A form of cancer, this disease can affect the sac lining, the chest or the abdomen. An unusual aspect about this disease is that it does not manifest itself for years following the asbestos exposure – in fact, the average manifestation time is 35-40 years later, and in some cases even 50 years later.

In previous years, asbestos was widely used in many places. Many people worked with this deadly material, unaware that several decades later it would be the death of them. Workers such as insulaters, plasterers, electricians, mechanics, bricklayers, carpenters, and other tradesmen were exposed to asbestos on a daily basis as it was contained in many insulation and construction materials.

However, it is not only those that were regularly exposed to asbestos that are at risk. There have been many cases of mesothelioma manifestation in people that were only exposed to asbestos for a short period of time. In fact, the disease has even been known to affect people who have had only minimal contact, such as wives that used to wash their husbands overalls after they had worked with asbestos.

The long latency period attached to mesothelioma means that the symptoms of this disease can take many years to manifest, making both diagnosis and effective treatment very difficult. And even when the symptoms do become evident, which can take several decades, the symptoms are so generalised and non-specific that they could be put down to any number of more common diseases. This makes it hard for even experienced doctors to make a quick and conclusive diagnosis with mesothelioma patients. The symptoms of this disease can often be confused with pneumonia during its early stages.

Some of the most common symptoms of pleural mesothelioma (which is the most common form of the disease) are shortness of breath and chest pains. This may be accompanied by a persistent cough, and all of these symptoms stem from the build up of fluid between the lining of the lung and the chest cavity. This is known as pleural effusion. This type of the disease starts in the chest cavity and can then spread to other parts of the body. Pleural mesothelioma sufferers may also begin to display severe breathing difficulty, weight loss and fever as well as trouble swallowing and even swelling of the face and neck. Some patients may also develop a rasping voice and start coughing up blood. However, there are other patients that may not show any significant symptoms at all.

The symptoms for patients who suffer from peritoneal mesothelioma (a rarer form of the disease) are slightly different. This type of the disease starts in the abdomen and can spread form there. Patients of peritoneal mesothelioma can display abdominal pain and swelling, nausea, loss of appetite and vomiting. They can also suffer breathing problems, and chest pain in addition to these symptoms. These symptoms result from tumors that lean against the abdominal wall. Bowel obstruction, anemia, fever and problems with blood clotting may also affect peritoneal mesothelioma patients.

The rarest form of this disease is pericardial mesothelioma, which starts in the cavity surrounding the heart. With pericardial mesothelioma, the tumors grow in the tissues that surround the heart and can spread from there. Pericardial mesothelioma sufferers may experience chest pain, shortness of breath, persistent coughing and palpitations.

Asbestos Exposure

Asbestos Exposure:

Is a mineral that can occur naturally in the environment, and is also used by man in a range of products. This material was once widely used in many places, but as the dangers of exposure to asbestos began to come to light, this all changed. However, for many people it was too late, as the damage had already been done. This is because asbestos is responsible for a number of side effects, which can cause anything from discomfort to death. Asbestosis and pleural plaques can result from exposure to asbestos, and more notably so can mesothelioma, a deadly cancer that can take many decades to develop but only a matter of months from the onset of symptoms to kill.

Mesothelioma is caused by ingesting or breathing in loose asbestos fibres, which can then cause scarring and ultimately can lead to this cancer. The cancer can affect the lung, chest, or abdominal cavities, but it also has a very long latency period, which means that it could be thirty years or more before the person even realizes that they have contracted the cancer because this is how long it can take to manifest. The onset of symptoms can take up to fifty years or more in some cases, but once the symptoms have manifested the lifespan of the person can be as short as several months.

Between the 1950s and the 1980s, many people – mainly men – worked in industries where they were exposed to asbestos on a daily basis and for long periods of time. This mineral was so widely used because it was cheap and because of its fire resistant properties. Because the effects of the mineral were largely unknown except for in certain circles at the time, workers did not question the lack of protection or concern displayed with regards to working so closely with asbestos.

However, it is thought that many companies and manufacturers were aware of the deadly effects of this mineral from as early as the 1920s. However, their failure to provide oblivious employees with protection against the effects of asbestos resulted in many people contracting this cancer, and only realizing thirty to fifty years down the line just as they were settling down to enjoy their retirement.

Some of the workers mostly likely to come across asbestos on a day to day basis and therefore most at risk included as insulators, plasterers, electricians, mechanics, bricklayers, carpenters, and other tradesmen. This is because these professionals worked closely with materials and products that contained asbestos. Also at risk were the families of these workers, as they could often ingest or breathe in asbestos fibres from the clothes, skin, or hair of the worker, and this could lead to the same effects.

Millions of workers have been exposed to asbestos over the years, and the unlucky ones have discovered several decades later just what an impact their work had on their health. Many of the cases of mesothelioma coming to light today are in men, as it was mainly men that worked with asbestos several decades ago. These workers are now finding out that they have this cancer and other asbestos related disorders, as the symptoms finally manifest.

The dangers of asbestos exposure have now been far more widely recognised. However, millions of people worldwide have been exposed to this mineral. For these people, living life can be like living on borrowed time, and each year, thousands of new cases of mesothelioma and other asbestos-related cancers are diagnosed.

This figure is likely to increase over the next ten years or so, and many more middle-aged and elderly people could find that they have been harbouring this deadly cancer for the past few decades.

Although it is now known that asbestos exposure is responsible for malignant mesothelioma and other forms of cancer, asbestosis, pleural plaques, and other respiratory and health problems, this mineral can still be found in insulation materials in many places worldwide, and therefore continues to hold its deadly reign over mankind.

Mesothelioma and Asbestos

Mesothelioma and Asbestos:

The cause of a number of ailments and diseases, including the deadly cancer mesothelioma, asbestos has actually been in use for centuries. The name asbestos was given to this mineral by the Ancient Greeks, and the word literally means inextinguishable. The Greeks gave it this name because of its amazing fireproof qualities, although they also noted the harmful effects that asbestos had upon workers.

Asbestos is a soft and flexible, which has been widely used for many years for a variety of things. The modern use for this mineral is for insulation, and it has been used in a wide range of items and structures, from ceilings and walls to toasters and hairdryers. This mineral became popular during the industrial revolution as an effective and safe form of insulation – safe in that it was fireproof, but certainly not safe in any other sense. Although the risks involved in using and working with asbestos had been observed several hundred years earlier, these risks were not taken into account when asbestos became widely used for insulation.

It was not until the 1900s that the facts regarding the risks involved to workers began to re-emerge. An English physician carried out a post-mortem on a man who had worked with asbestos for many years, and he found traces of fibres and dust in the man’s lungs. The doctor stated that the man had died due to his exposure to this mineral. Over the next twenty or so years professionals in many countries began to notice the fact that disease, illness and death was uncommonly high amongst asbestos workers.

In the mid 1920s, an English doctor made the first diagnosis of asbestosis, and this was followed by a study which showed that 25% of English asbestos workers showed signs of a related lung disease. Laws were then stepped up in England to provide better ventilation and more protection to workers who were regularly exposed to asbestos. These steps were slowly followed by other countries over the next decade.

This protection was slow to be implemented and did not prove all that effective. Although asbestos manufacturers and companies that used the mineral were now aware of these studies and the risks involved to workers, they continued to use asbestos widely, exposing many workers to the hazards associated with it. These employees continued to work with asbestos, totally oblivious of the harm that it was capable of causing. Asbestos continued to be widely used until the mid-seventies, by which time many workers has been exposed and were already unknowingly affected by what we now know as mesothelioma.

Today, as the disease begins to take its toll on the asbestos workers of the 1950s, 1960s and 1970s, many new cases of the disease are being diagnosed each year. In fact, the number of cases is rising so quickly that many law firms have employed or trained lawyers to deal specifically with these types of cases. The irresponsible companies and manufacturers that were responsible for this exposure have been sued for billions of dollars, with many of them going bankrupt as a result of compensation payouts.

Although the effects of asbestos have been observed, tested and verified, this mineral is still used today in many places around the world. Although the laws and regulations regarding working with asbestos are far more stringent these days, this doesn’t change the fact that this mineral can cause more harm than good and has claimed many victims from all over the world in the form of the deadly disease mesothelioma

Diagnosing Mesothelioma

Diagnosing Mesothelioma:

The diagnosis of mesothelioma is not always easy. Many doctors are still unfamiliar with the symptoms which could be put down to a number of other, more common diseases. Timely diagnosis of mesothelioma is particularly difficult because of the latency period between contraction and display of symptoms. The symptoms of this cancer may not become evident for decades, which means that by the time it is diagnosed it is in its latter stages and there is little that can be done for the patient.

There are many symptoms that become evident in Pleural mesothelioma patients, many of which are common symptoms in a variety of illnesses and diseases, hence the difficulty in diagnosis. Lower back pain, chest pain and shortness of breath are symptoms of the disease. Some patients also suffer from excessive perspiration, trouble swallowing, weight loss and tiredness. The disease affects the respiratory system, and results from an accumulation of fluid between the lung lining and chest cavity, known as pleural effusion. The other type of mesothelioma, which affects the abdominal lining, is known as peritoneal mesothelioma. The symptoms that may be displayed by patients include nausea, vomiting, weight loss and stomach pains.

The diagnosis of mesothelioma will entail scans and biopsies arranged by your doctor. A CT or MRI scan is often used to detect the possible presence of the disease, and if there is a positive indication of the presence of mesothelioma, the scans are followed up by a biopsy. Doctors often run an examination on the fluid surrounding the lungs, but all too often this is inadequate to make a firm diagnosis. In these circumstances the doctor may perform a small operation in order to remove a tissue sample and run a biopsy on that. This is known as open pleural biopsy. If you are suspected of suffering from peritoneal mesothelioma the biopsy will be performed on tissue taken from the abdominal area, known as a peritoneal biopsy.

Although the open biopsy procedures are considered to be the most effective and conclusive ways of diagnosing mesothelioma according to experts, there are a range of other procedures that doctors may use in order to try and determine whether a patient has the disease.

The testing procedure will start with imaging tests, such as x-rays, CT scans or MRI scans. This will enable the doctor to view the potentially affected area and make a preliminary diagnosis and decide upon the best course of action. The doctor may then use a needle to remove fluid from the affected area and conduct tests to see whether there are any malignant cells present. However, this test is widely thought of as inconclusive and many doctors prefer to follow it up with a tissue biopsy whether or not malignant cells are present.

There are several ways in which the doctor can perform a tissue biopsy in order to test for mesothelioma. A thoracoscopy or laparoscopy entails making a small incision and using a tiny camera to look at the affected area. At this time a small tissue sample can be taken, which is then examined by a pathologist for signs of mesothelioma. Your doctor may decide to do a needle biopsy, where a hollow needle is inserted through the skin and into the chest cavity. The doctor is able to collect a tissue sample with the needle, and this is then examined by the pathologist.

However, most physicians prefer to use an open biopsy as this allows for the collection of a bigger tissue sample making diagnosis easier and more accurate. Once the tissue samples have been collected, a detailed examination of the cells is performed to check for malignant cells in the tissue. Once a diagnosis has been made, further scans may be required to learn the extent of the disease and prescribe treatment.

If you have worked with or had contact with asbestos at any time in your life, it is important that you let your doctor know. The difficulty in diagnosing mesothelioma means that you doctor may put your symptoms down to any number of diseases before testing for mesothelioma. However, if you have already made it known that you have worked with asbestos, it will give the doctor a head start in making a diagnosis. This means that test can be carried out far earlier and the necessary treatment can be prescribed.

Symptoms of Mesothelioma

Symptoms of Mesothelioma:

The long latency period attached to mesothelioma means that the symptoms of this disease can take many years to manifest, making both diagnosis and effective treatment very difficult. And even when the symptoms do become evident, which can take several decades, the symptoms are so generalised and non-specific that they could be put down to any number of more common diseases. This makes it hard for even experienced doctors to make a quick and conclusive diagnosis with mesothelioma patients. The symptoms of this disease can often be confused with pneumonia during its early stages.

Some of the most common symptoms of pleural mesothelioma (which is the most common form of the disease) are shortness of breath and chest pains. This may be accompanied by a persistent cough, and all of these symptoms stem from the build up of fluid between the lining of the lung and the chest cavity. This is known as pleural effusion. This type of the disease starts in the chest cavity and can then spread to other parts of the body. Pleural mesothelioma sufferers may also begin to display severe breathing difficulty, weight loss and fever as well as trouble swallowing and even swelling of the face and neck. Some patients may also develop a rasping voice and start coughing up blood. However, there are other patients that may not show any significant symptoms at all.

The symptoms for patients who suffer from peritoneal mesothelioma (a rarer form of the disease) are slightly different. This type of the disease starts in the abdomen and can spread form there. Patients of peritoneal mesothelioma can display abdominal pain and swelling, nausea, loss of appetite and vomiting. They can also suffer breathing problems, and chest pain in addition to these symptoms. These symptoms result from tumours that lean against the abdominal wall. Bowel obstruction, anaemia, fever and problems with blood clotting may also affect peritoneal mesothelioma patients.

The rarest form of this disease is pericardial mesothelioma, which starts in the cavity surrounding the heart. With pericardial mesothelioma, the tumours grow in the tissues that surround the heart and can spread from there. Pericardial mesothelioma sufferers may experience chest pain, shortness of breath, persistent coughing and palpitations.

As the disease moves into the later stages, the symptoms for all types of mesothelioma become more acute and obvious, although they can still often be put down to another illness. It is therefore important for patients to inform their doctor if they have been exposed to asbestos at any point – or even if they suspect they may have been exposed to asbestos. This will enable the doctor to make a more informed diagnosis rather than basing his diagnosis on guess work. It is also important not to ignore any of these symptoms, especially if they are experienced over a long period. Many people can be exposed to asbestos inadvertently (e.g. through the clothes of someone that has worked with asbestos) so it is important to visit your doctor should any of these symptoms manifest.

With pleural mesothelioma being the most common form of the disease, the symptom associated with this form of the cancer are the most common ones that are displayed by patients. However, it is important to be fully aware of the symptoms for all three types of mesothelioma, particularly for those who have worked in high risk professions where they may have been exposed to asbestos.

Most people who have worked with asbestos in the past do not begin to show symptoms of mesothelioma until thirty to forty years later. By this time, the disease is already spreading and with the delay in diagnosis, makes it impossible to treat in many cases before it is too late. However, the cause, effects and symptoms of mesothelioma are now becoming more widely known by professionals and lay people. This awareness, coupled with the current clinical trials that are being carried out by a variety of organizations gives patients the hope that an effective treatment will one day be available for all stages of the disease.

Pericardial mesothelioma

Pericardial mesothelioma is the rarest form of this asbestos-related cancer. This form of cancer affects the lining that surrounds the heart, and is associated with long term exposure to asbestos fibres.

The symptoms of pericardial mesothelioma, as with other types of mesothelioma, can take decades to manifest. If a person worked with asbestos twenty or thirty years ago and shows no symptoms, that does not mean that they have the all clear. The symptoms typically take around twenty or thirty years to manifest anyway, sometimes even longer.

This means that the cancer is usually too advanced to treat effectively by the time it is diagnosed. It is always advisable that people who have worked with asbestos on a frequent basis in the past inform their doctors. Although nothing can be done to speed up the onset of symptoms in order to catch the disease in time to treat, any further delay in diagnosis can be alleviated by making your doctor aware of all the facts so that a speedy diagnosis can be made if the symptoms to manifest.


There are several main symptoms to look out for with pericardial mesothelioma. These include: persistent coughing; shortness of breath; chest pain; palpitations. Anyone that has worked with asbestos and experiences any or all of these symptoms should seek medical advice immediately.

Once your doctor has made a diagnosis, it is important to assess the extent to which the disease has spread and to what degree it has advanced. This is usually determined by imaging. A CT Scan or MRI Scan can normally reveal what stage the disease is at, and this will help to determine what sort of treatment can be considered. The patient’s age, medical condition, and past medical history will also be taken into account when deciding upon a course of treatment.


Pericardial mesothelioma can occasionally be treated with surgery. However, the nature of this cancer means that it is very advanced by the time that it is diagnosed and this often means that surgery for this particular type of mesothelioma has to be ruled out. Even if surgery is performed, it is unlikely that all of the tumour or cells can be removed or treated, hence further treatment of radiation or chemotherapy (known as systemic treatments) is needed afterwards anyway.

The two most common forms of treatment for pericardial mesothelioma are radiation therapy or chemotherapy. Radiation therapy is the most commonly used of the two procedures for this type of mesothelioma, and the one that has proven most successful with pericardial mesothelioma patients to date. However, both types of treatment must be carefully monitored due to the risk they pose to healthy cells as well as affected ones.

Another low risk procedure often used simply to relieve symptoms is a ‘fine needle aspiration.’ This is where a needle is inserted into the chest cavity in order to drain off excess fluid build up caused by the cancer. This can often relieve some of the symptoms of the disease.

Clinical trials into all types of mesothelioma are still being continued all over the country and all over the world. Many patients find that it helps to be a part of a clinical trial as it gives them a chance to try a new form of treatment that could be effective, as well as giving them hope and making them feel more positive. And it is through this type of positive attitude along with the hard work of the professionals that, one day, a cure for all types of mesothelioma at all stages could be discovered.

Treatment for Pleural Mesothelioma

Treating pleural mesothelioma is dependant on many things, and it is the doctor that will normally suggest the recommended course of treatment based upon his knowledge and the findings from his diagnostic tests. Factors such as the patient’s age, medical history, general well being, and even weight, are taken into account. Other factors that have to be considered include: how far the cancer has spread; and where the cancer is.

The treatments for the different types of mesothelioma are more or less the same in most cases, but obviously they are targeted towards different areas of the body depending upon which area has been affected by the cancer.

These treatments include:

Surgery:

This may entail moving part or all of a lung and some of the surrounding tissue in order to remove the tumour and cancerous cells. It may also be necessary to drain the lungs of fluid, simply to make the patient more comfortable. The extent of surgery will depend largely upon the extent to which the cancer has spread.


Chemotherapy:

For this procedure, drugs are used to fight the cancerous cells and kill them as well as shrink the tumour. These drugs can be swallowed by mouth if they are in tablet form, or the doctor may administer them needle directly into a vein or muscle. The drugs are then able to travel through the body via the blood stream and kill off any cancer cells that they come across.


Radiation Therapy:

This is where high energy x-rays are used either outside the body (external radiation) or directed to the source internally (internal radiation) to shrink the tumour and kills off cancer cells. Internal radiation is preformed through the use of plastic tubing, where the doctor can also administer drugs.

Pleural Mesothelioma

Pleural Mesothelioma is the most common form of mesothelioma that exists, and in its malignant form is the direct result of exposure to asbestos fibres. You can get benign tumours with mesothelioma, but the malignant form is by far the most common. The breathing in of asbestos fibres is what puts those who work unprotected with asbestos at risk, and the risks can be heightened by smoking as well as exposure to this hazardous fibre.

This form of mesothelioma attacks the lungs and respiratory areas of the body. The cancer attacks the cells and the lining (known as the pleura) of the lungs and ribs. As with other forms of mesothelioma, the symptoms can take twenty or thirty years (sometimes longer) to present themselves following exposure to asbestos, making it impossible for people to realise that they have been affected until it is too late.

There are a number of symptoms for pleural mesothelioma, and like peritoneal mesothelioma, they can appear very non-specific and could be put down to a number of common diseases or illnesses. The long latency period associated with mesothelioma is already the cause of much delay, but the type of symptoms associated with this disease can cause even further delay, even when the onset begins.

Without prior knowledge that you have worked with asbestos and are therefore a high risk patient where mesothelioma is concerned, your doctor could end up testing for a wide range of other diseases such as pneumonia. This wastes much needed time, and it is therefore vital that you not only keep your eyes open for any of the associated symptoms but also inform your doctor of your past history of working with asbestos. Armed with this information, the doctor can then start running appropriate tests should the symptoms manifest

Some of the symptoms that are commonly associated with pleural mesothelioma include: persistent coughing; difficulty swallowing; facial swelling; weight loss; fever; rasping; and coughing up blood. Some patients may also experience shortness of breath, whether they are being active or even when they are resting. This can be caused by the thickening of the pleura due to the spread of the tumour. The thicker the pleura gets, the less space the lungs have to function properly, hence breathing begins to be affected.

Some patients may also experience severe pain in the chest or ribs, and this is caused by the spread of the cancerous cells and the tumour. Should the tumour start to spread outwards, it will affect the chest area as well as the lungs.